Abstract

To achieve the desired results in a more reliable way of research in the health studies, application of in vivo methods has been increasing. Among in vivo methods, use of laboratory animals is one of the appropriate and reliable methods particularly for human disease experiments. Investigating the studies using laboratory animals, most of the experiments seem to be conducted on human health. However, although the results of experiments with laboratory animals are similar to the experiments with humans, differences between human and animal metabolism causes an important issue when ignored. Animal species, strain, sex, nature of the chemicals to be used in research play a great role in creating the right model. Hereby, while the possibility of getting the right result increases compliance with 3R rules would be preserved. In this review, the importance of strains in the creation of animal models were examined.